Genetic and Environmental Susceptibility to Multiple Sclerosis

Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis

Modelling genetic susceptibility to multiple sclerosis with family data.

A genetic contribution to susceptibility is well established in multiple sclerosis (MS) and 57 associated genetic loci have been identified. We have undertaken a meta-analysis of familial risk studies with the aims of providing definitive figures for risks to relatives, performing a segregation analysis and estimating the proportion of the overall genetic risk that currently identified genes re...

IL-33 polymorphism rs1929992 and its association with susceptibility to different pattern of multiple sclerosis

Background: Multiple sclerosis is the most common autoimmune demyelinating disease of the central nervous system (CNS). Interleukin-33 (IL-33) is a cytokine with both pro-inflammatory and anti-inflammatory activities that implicated in the pathogenesis of some autoimmune diseases. The aim of this study was to determine single nucleotide polymorphism (SNP) of IL-33, rs1929992, in patient’s gene ...

The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect.

The remarkably low rate of concordance of multiple sclerosis (MS) in monozygotic twins has never been fully explained but it implies the possibility of a systemic condition called the multiple sclerosis trait (MST), which is quite different from asymptomatic MS. It results from the action of an antigenic challenge on the immune system of a genetically vulnerable person that does not cause damag...

Selected genetic factors contributing to susceptibility to multiple sclerosis as well as to disease outcome